Характеристика физико-химических свойств, антиоксидантной, антимутагенной и репаративной активности нанокомплексов куркуминоидов с циклодекстринами

Методом ИК-спектроскопии и термического анализа проведена характеристика спектральных свойств и термостабильности нанокомплексов куркуминоидов с циклодекстринами, рассчитаны изменения энергии активации термодеструкции куркуминоидов при формировании нанокомплексов. В модельной системе восстановления радикал-катиона АВТS˙+ определены значения IC50 для нанокомплексов куркуминоидов с β-циклодекстрином (КД:β-ЦД) и 2-гидроксипропил-бетациклодекстрином (КД:ГП-β-ЦД), полученных методом соиспарения и лиофилизации при соотношении 1:2, которые составили 1,076 г/л и 0,161 г/л соответственно. С использованием теста Эймса показано наличие антимутагенной активности препаратов КД:β-ЦД и КД:ГП-β-ЦД. При внесении в среду инкубации препарата нанокомплексов КД:ГП-β-ЦД 1:2 наблюдалось достоверное снижение частоты мутагенеза на 50% по сравнению с контролем. Применение нанокомплексов КД:β-ЦД 1:2 в качестве ранозаживляющего средства на модели лоскутной раны кожи у крыс линии Вистар показало течение регенерацтивного процесса по пути органотипической регенерации.

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