DEVELOPMENT AND RESEARCH OF DOSAGE FORMS WITH CETIRIZI

Abstract

The development of new dosage forms with cetirizine is an urgent problem. Cetirizine has an optimally low volume of distribution among the available antihistamines of the second genera-tion-0.5 l/kg . Due to these properties, it provides a minimum level of negative interactions with other drugs, a minimum variability of the therapeutic effect in different patients and a minimum risk of dose-dependent toxic effects on organs and tissues. Cetirizine effectively corrects the symptoms of allergic reactions and improves the quality of life ofpatients. Cetirizine preparations are worthy representatives of antihistamines, drugs with a significant evidence base, which allows us to pro-vide patients with an allergological profile with effective, safe and affordable drugs. Currently, the following drugs with cetirizine are available: film-coated tablets and dispersible tablets in the oral cavity, as well as drops for oral administration. There are no transdermal dosage forms with ce-tirizine in Russia. The transdermal therapeutic system - TTS) is a metered-dose, soft dosage form for external use in the form of gels, patches, or films that release the drug slowly. Advantages of TTS: ease of use, the drug quickly enters the blood, the ability to regulate the rate of release of the active sub-stance, the ability to use hydrophilic and lipophilic substances. We developed two transdermal therapeutic systems with cetirizine-gel and patch, and stud-ied the pharmacological effects.