NONSTATIONARY PHARMACOKINETICS ON A MATHEMATICAL MODEL
https://doi.org/10.37493/2307-910X.2022.4.2
Abstract
In practice, algorithms and models of sorption and desorption of substances by a living organism are more in demand, when their regular intake is unchanged throughout the observation time interval. As a rule, these are environmental conditions, harmful industries or long-term treatment of chronic diseases. But no less interesting is the solution of a more general, nonstationary multidimensional problem, including both the case of sorption and desorption in the body of one ingredient acting according to some function, and cases when several ingredients are involved in the process. At the same time, the half-life a priori known for each of them is considered dependent on the already accumulated amount of other substances in the body. In this paper, the most general case is investigated using a mathematical model, up to the possibility of active intervention in metabolism that does not violate homeostasis.
About the Authors
V. A. Utkin
Center for Biomedical Technologies of the North Caucasus Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Utkin Vladimir A., Doctor of Medical Sciences, Leading Researcher
Essentuki
T. V. Kukharova
SaintPetersburg State University of Aerospace Instrumentation)
Russian Federation
Russian Federation
Kukharova Tatyana V., Candidate of Technical Sciences, Associate Professor of the Department of Biotechnical Systems and Technologies
St. Petersburg
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Review
For citations:
Utkin V.A., Kukharova T.V. NONSTATIONARY PHARMACOKINETICS ON A MATHEMATICAL MODEL. Modern Science and Innovations. 2022;(4):25-30. https://doi.org/10.37493/2307-910X.2022.4.2
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