THE STUDY OF THE INFLUENCE OF THE DRUG «TIENAM» ON THE ACTIVITY OF SOME ENZYMES OF BLOOD SERUM

Abstract

A study of biochemical profile and urine composition in experimental animals in 14-day drug "Tienam" in a dose of650 mg/kg showed increased activity of alanine aminotransferase at 30 %, while the aspartate aminotransferase activity both in females and males was at the level of the control values. The activity of alkaline phosphatase increased in comparison with control females and males (less pronounced) at 141 % and 15 % respectively with the introduction of Tienam at a dose of650 mg/kg. After 14-day administration of Tienam in doses 130,0 mg/kg and 650 mg/kg experimental groups of animals - females marked decrease in the activity of this indicator was 41 % and 64 %, respectively. In groups of males lactate dehydrogenase activity was also significantly decreased compared to control at 44 % with the introduction of Tienam at a dose of 650 mg/kg. a study of the status of these indicators in 14 days after discontinuation of the drug did not reveal shifts that have deviations from physiological norms.