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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">msi</journal-id><journal-title-group><journal-title xml:lang="ru">Современная наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2307-910X</issn><publisher><publisher-name>North-Caucasus Federal University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37493/2307-910X.2021.2.10</article-id><article-id custom-type="elpub" pub-id-type="custom">msi-311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕХНОЛОГИЯ ПРОДОВОЛЬСТВЕННЫХ ПРОДУКТОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TECHNOLOGY OF FOOD PRODUCTS</subject></subj-group></article-categories><title-group><article-title>Коррекция иммунодефицита мышей биологически активным веществом тканевого происхождения</article-title><trans-title-group xml:lang="en"><trans-title>Correction of immunodeficiency in mice with a biologically active substance of tissue origin</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кольберг</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolberg</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">kolberg_na@usue.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонов</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonov</surname><given-names>S. L.</given-names></name></name-alternatives><email xlink:type="simple">tihonov75@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">tihonov75@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьева</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontyeva</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">leontsa@usue.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Уральский государственный экономический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Economic University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>04</day><month>08</month><year>2022</year></pub-date><volume>0</volume><issue>2</issue><fpage>107</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кольберг Н.А., Тихонов С.Л., Тихонова Н.В., Леонтьева С.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кольберг Н.А., Тихонов С.Л., Тихонова Н.В., Леонтьева С.А.</copyright-holder><copyright-holder xml:lang="en">Kolberg N.A., Tikhonov S.L., Tikhonova N.V., Leontyeva S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://msi.elpub.ru/jour/article/view/311">https://msi.elpub.ru/jour/article/view/311</self-uri><abstract><p>Иммунодефицитные состояния, при которых возникает иммунная недостаточность или формируется как слабый иммунный ответ на внедрение антигена. Первичное иммунодефицитное состояние (ПИД) - это заболевания иммунной системы, которые передаются по наследству. Известно более 400 таких заболеваний Своевременная информативность о наличии ПИД позволяет своевременно проводить профилактику рецидивов и лечение. Поэтому, зная этиологию ПИД так как он является приобретенным клинико-иммунологическим синдромом, его можно устранить путем ликвидации вызывающих его причин, на развитие ПИД влияет возраст, несбалансированное питание, нарушение обмена веществ (сахарный диабет), внешние факторы, способные вызвать стрессовое состояние, воздействие радиактивного, ультрафиолетового излучения, и т..д. В связи с этим существует необходимость поиска рациональной профилактике ПИД, путем ликвидации причин возникновения и восстановления иммунного статуса организма с помощью биологически активных веществ иммуномодулирующего действия с отсутствием побочных эффектов.</p></abstract><trans-abstract xml:lang="en"><p>Immunodeficiency conditions in which immune deficiency occurs or is formed as a weak immune response to the introduction of an antigen. Primary immunodeficiency (PID) is a disease of the immune system that is inherited. More than 400 such diseases are known. Timely information about the presence of PID allows timely prevention of relapses and treatment. Therefore, knowing the etiology of PID, since it is an acquired clinical and immunological syndrome, it can be eliminated by eliminating the causes that cause it, the development of PID is influenced by age, unbalanced nutrition, metabolic disorders (diabetes mellitus), external factors that can cause stress, exposure to radioactive, ultraviolet radiation, etc..d. In this regard, there is a need to search for a rational prevention of PID, by eliminating the causes of the occurrence and restoring the immune status of the organism with the help of biologically active substances of immunomodulatory action with the absence of side effects.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биологически активное вещество</kwd><kwd>тканевый препарат</kwd><kwd>экстракт фабрициевой сумки цыплят бройлеров</kwd><kwd>цитотоксичность</kwd><kwd>иммунитет</kwd><kwd>пролиферативная активность лимфоцитов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>biologically active substance</kwd><kwd>tissue preparation</kwd><kwd>bursa extract of broiler chickens</kwd><kwd>cytotoxicity</kwd><kwd>immunity</kwd><kwd>proliferative activity of lymphocytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bousfiha A.A., Jeddane L., Ailal F. et al. 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