The article examines the significant systemic effect of religious-oriented INGOs on the international political arena as subjects of world politics, since the world political processes in the XXI century increasingly reflect the functioning of international non-governmental organizations of religious orientation (INGOs of religious orientation), which in their communication with secular and religious organizations show the paradox of substitution of the qualities of the functions performed, determined by their institutional nature. It is concluded that the fundamental criteria that should distinguish religious-oriented INGOs from other non-governmental international organizations, such as communicating religious values, strengthening the spiritual ties of parishioners and Churches, recognizing mutual responsibility to each other, are supplemented by religious and political content.