msiСовременная наука и инновацииModern Science and Innovations2307-910XNorth-Caucasus Federal University10.37493/2307-910X.2022.3.26msi-1417Research ArticleДИСКУССИОННЫЕ СТАТЬИDISCUSSION PAPERSПерспективы применения чистяка весеннего Ficaria verna huds в медицине и пищевой промышленности, химический состав и биологическая активностьThe prospects of application of spring chistyak Ficaria verna huds in medicine and food industry, chemical composition and biological activityКоноваловД. А.KonovalovD. A.

Коновалов Дмитрий Алексеевич - доктор фармацевтических наук, профессор, заместитель директора по научной работе, ПМФИ – филиал ВолгГМУ Минздрава России.

357532, Ставропольский край, Пятигорск, проспект Калинина, 11

Тел.: +7 (928) 351-93-49

Dmitry A. Konovalov - Doctor of Pharmaceutical Sciences, Professor, Deputy Director for Research, Pyatigorsk Medical and Pharmaceutical Institute - branch of the VolgGMU of the Ministry of Health of Russia.

357532, Stavropol Territory, Pyatigorsk, Kalinin Avenue, 11

Tel.: +7 (928) 351-93-49

d.a.konovalov@pmedpharm.ruЗолотыхД. С.ZolotykhD. S.

Золотых Денис Сергеевич - кандидат фармацевтических наук, доцент кафедры аналитической и токсикологической химии.

357532, Ставропольский край, Пятигорск, проспект Калинина, 11

Тел.: +7 (928) 351-93-49

Denis S. Zolotykh - Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Analytical and Toxicological Chemistry, Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volga State Medical University of the Ministry of Health of Russia.

357532, Stavropol Territory, Pyatigorsk, Kalinin Avenue, 11

Tel.: +7 (928) 351-93-49

metronidazol@mail.ruПоздняковД. И.PozdnyakovD. I.

Поздняков Дмитрий Игоревич - кандидат фармацевтических наук, доцент кафедры фармакологии с курсом клинической фармакологии.

357532, Ставропольский край, Пятигорск, проспект Калинина, 11

Тел.:  +7 (928) 351-93-49

Dmitry I. Pozdnyakov - Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmacology with a Course in Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volga State Medical University of the Ministry of Health of Russia.

357532, Stavropol Territory, Pyatigorsk, Kalinin Avenue, 11

Tel.: +7 (928) 351-93-49

pozdniackow.dmitry@yandex.ruПятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава РоссииРоссияPyatigorsk Medical and Pharmaceutical Institute - branch of the VolgGMU of the Ministry of Health of RussiaRussian FederationПятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава РоссииРоссияPyatigorsk Medical and Pharmaceutical Institute - branch of the Volga State Medical University of the Ministry of Health of RussiaRussian Federation20221501202303246263Copyright © Коновалов Д.А., Золотых Д.С., Поздняков Д.И., 20232023Коновалов Д.А., Золотых Д.С., Поздняков Д.И.Konovalov D.A., Zolotykh D.S., Pozdnyakov D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://msi.elpub.ru/jour/article/view/1417

Ficaria verna – многолетнее травянистое инвазивное растение, широко распространѐнное в России. В качестве основных групп биологически активных соединений его надземной части описаны фенольные (флавоноиды, фенолокислоты), терпеновые (тритерпеновые, каротиноиды, фитостеролы, фталаты) соединения.

Растение использовалось в народной медицине некоторых европейских стран при лечении кашля, цинги, геморроя, а также как гепатопротекторное средство. В качестве токсического вещества, содержащегося в растении, описан протоанемонин – нестабильный летучий лактон, легко преобразующийся в нетоксичное соединение анемонин.

Исследование различных извлечений из Ficaria verna позволило установить их антиоксидантную, противовоспалительную и антимикробную активность, что представляет несомненный интерес для дальнейшего более глубокого изучения.

В обзоре представлены научные данные, полученные из доступных открытых источников литературы, содержащие информацию о биологически активных веществах широко распространённого растения – чистяка весеннего. Кроме того, приведены сведения об использовании данного вида и извлечений на его основе в народной и научной медицине, установленной биологической и фармакологической активности и токсичности.

Ficaria verna is a perennial herbaceous invasive plant widely distributed in Russia. Phenolic (flavonoids, phenolic acids), terpene (triterpene, carotenoids, phytosterols, phthalates) compounds are described as the main groups of biologically active compounds of its aerial part.

The plant was used in folk medicine in some European countries in the treatment of cough, scurvy, hemorrhoids, and also as a hepatoprotective agent. As a toxic substance contained in the plant, protoanemonin is described - an unstable volatile lactone, which is easily converted into a non-toxic compound anemonin.

The study of various extracts from Ficaria verna made it possible to establish their antioxidant, antiinflammatory and antimicrobial activity, which is of undoubted interest for further in-depth study.

The review presents scientific data obtained from available open sources of literature containing information on biologically active substances of a widespread spring chistyak plant. In addition, information is provided on the use of this species and extracts based on it in folk and scientific medicine, established biological and pharmacological activity and toxicity.

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The authors declare that there are no conflicts of interest present.