<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">msi</journal-id><journal-title-group><journal-title xml:lang="ru">Современная наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2307-910X</issn><publisher><publisher-name>North-Caucasus Federal University</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">msi-1142</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL AND BIOLOGICAL SCIENCES</subject></subj-group></article-categories><title-group><article-title>ИЗУЧЕНИЕ ВЛИЯНИЯ ПРЕПАРАТА «КОМБИВИР» НА ПОКАЗАТЕЛИ УГЛЕВОДНОГО И ЛИПИДНОГО ОБМЕНОВ СЫВОРОТКИ КРОВИ</article-title><trans-title-group xml:lang="en"><trans-title>THE STUDY OF INFLUENCE OF PREPARATION «COMBIVIR» ON CARBOHYDRATE AND LIPID METABOLISM OF BLOOD SERUM</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Елена Олеговна</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>Elena Olegovna</given-names></name></name-alternatives><email xlink:type="simple">maklea@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саджая</surname><given-names>Любовь Анатольевна</given-names></name><name name-style="western" xml:lang="en"><surname>Sadjaya</surname><given-names>Lubov Anatolievna</given-names></name></name-alternatives><email xlink:type="simple">belochka794@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терехов</surname><given-names>Александр Юрьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Terekhov</surname><given-names>Alexander Yurievich</given-names></name></name-alternatives><email xlink:type="simple">tau200@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО ВолгГМУ Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GBOU VPO Volgograd state medical University Ministry of health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>4</issue><fpage>119</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сергеева Е.О., Саджая Л.А., Терехов А.Ю., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Сергеева Е.О., Саджая Л.А., Терехов А.Ю.</copyright-holder><copyright-holder xml:lang="en">Sergeeva E.O., Sadjaya L.A., Terekhov A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://msi.elpub.ru/jour/article/view/1142">https://msi.elpub.ru/jour/article/view/1142</self-uri><abstract><p>Целью данного исследования явилась оценка влияния препарата «Комбивир»на показатели обмена углеводов и липидов сыворотки крови при изучении общетоксического действия, проводимого в условиях хронического эксперимента.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of this study was to evaluate the effect of the drug «Combivir» on indicators of carbohydrate metabolism and serum lipids in the systemic toxicity study conducted in conditions of chronic experiment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ВИЧ-инфекция</kwd><kwd>ламивудин</kwd><kwd>зидовудин</kwd><kwd>синергизм</kwd><kwd>HIV infection</kwd><kwd>lamivudine</kwd><kwd>zidovudine</kwd><kwd>synergy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бартлетт Д., Галлант Д., Фамп П. Клинические аспекты ВИЧ-инфекции 2009-2010. - М.: Р. Валент, 2010.</mixed-citation><mixed-citation xml:lang="en">Бартлетт Д., Галлант Д., Фамп П. Клинические аспекты ВИЧ-инфекции 2009-2010. - М.: Р. Валент, 2010.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Василенко Ю. К. Клинико-биохимические основы патологии и биохимической лабораторной диагностики: учеб. пособие. - Пятигорск: Ротапринт ПятГФА, 2005. - 112 с.</mixed-citation><mixed-citation xml:lang="en">Василенко Ю. К. Клинико-биохимические основы патологии и биохимической лабораторной диагностики: учеб. пособие. - Пятигорск: Ротапринт ПятГФА, 2005. - 112 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Камышников В. С. Справочник по клинико-биохимической лабораторной диагностике: В 2 т. - Минск: Беларусь, 2000. Т. 2. - 463 с.</mixed-citation><mixed-citation xml:lang="en">Камышников В. С. Справочник по клинико-биохимической лабораторной диагностике: В 2 т. - Минск: Беларусь, 2000. Т. 2. - 463 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по проведению доклинических исследований лекарственных средств / под ред. А. Н. Миронова. - М.: Гриф и К, 2012. ч.1. - 944 с.</mixed-citation><mixed-citation xml:lang="en">Руководство по проведению доклинических исследований лекарственных средств / под ред. А. Н. Миронова. - М.: Гриф и К, 2012. ч.1. - 944 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Сернов Л. Н. Элементы экспериментальной фармакологии / Л. Н. Сернов, В. В. Гацура. - М.: Наука, 2000. - 352 с.</mixed-citation><mixed-citation xml:lang="en">Сернов Л. Н. Элементы экспериментальной фармакологии / Л. Н. Сернов, В. В. Гацура. - М.: Наука, 2000. - 352 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chun T. W. et al. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proceedings of the National Academy of Sciences, 1998, 95(15):8869-8873.</mixed-citation><mixed-citation xml:lang="en">Chun T. W. et al. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proceedings of the National Academy of Sciences, 1998, 95(15):8869-8873.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Donnell D. et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet, 2010, 375(9731):2092-2098.</mixed-citation><mixed-citation xml:lang="en">Donnell D. et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet, 2010, 375(9731):2092-2098.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Finzi D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Medicine, 1999, 5(5):512-517.</mixed-citation><mixed-citation xml:lang="en">Finzi D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Medicine, 1999, 5(5):512-517.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hogg R. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet, 2008, 372(9635):293-299.</mixed-citation><mixed-citation xml:lang="en">Hogg R. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet, 2008, 372(9635):293-299.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mocroft A. et al. Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group. Lancet, 1998, 352(9142):1725-1730.</mixed-citation><mixed-citation xml:lang="en">Mocroft A. et al. Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group. Lancet, 1998, 352(9142):1725-1730.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mofenson L. M. et al. Risk factors for perinatal transmission of human immunodefciency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team. New England Journal of Medicine, 1999, 341(6):385-393.</mixed-citation><mixed-citation xml:lang="en">Mofenson L. M. et al. Risk factors for perinatal transmission of human immunodefciency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team. New England Journal of Medicine, 1999, 341(6):385-393.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Palella F. J. et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. New England Journal of Medicine, 1998, 338(13):85360.</mixed-citation><mixed-citation xml:lang="en">Palella F. J. et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. New England Journal of Medicine, 1998, 338(13):85360.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
